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Sept. 7. 2006 — The first medicate developed specifically for prematureejaculation performed well in two clinical trials but the new treatmentprobably won’t be available in the U. S any time soon. Men in the study who took the experimental medicate Dapoxetine developed byJohnson & Johnson Pharmaceuticals in conjunction with ALZA Corp. were ableto maintain erections longer than men who took placebos. Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) but isslightly different from the SSRIs (such as Zoloft. Paxil and Prozac) widelyprescribed for depression and otherpsychiatric disorders. The drug was designed to be taken as needed one to three hours before sex,instead of every day. Also it is eliminated from the body more quickly thanother SSRIs. Hopes that Dapoxetine would become the first drug approved for prematureejaculation dimmed last October when the FDA sent a “not approvable”letter to the manufacturer. The FDA’s concerns about the drug were not made public. In a news release,ALZA Corp promised to “communicate questions raised in the FDAletter.” A spokesperson for Johnson & Johnson told WebMD Thursday that thecompany “remains committed to the global development” ofDapoxetine. Those who do are often advised on practice techniques to back up. Some receivea prescription for a traditional long-acting SSRI since delayed ejaculationis a common side effect among men who act SSRIs for depression. This use of traditional SSRIs would be considered off-label since themedications are not specifically indicated for this problem. Other potential sexual align effects of SSRIs consider erectiledysfunction and loss of libido however making the traditionalantidepressants less than ideal for treatment of premature ejaculation. Jon L. Pryor. MD tells WebMD. Pryor is a urology professor at the University ofMinnesota. With treatment the average measure to ejaculation was 1.75 minutes in theplacebo-treated men. 2.78 minutes in the men treated with 30 milligrams ofDapoxetine and 3.32 minutes in the men treated with 60 milligrams of the medicate. The study lasted three months. “A bring together of minutes may not sound like much but for these guys it washuge,” Pryor says. Men who took the short-acting SSRI also reported having more hold back overtheir ejaculations than the placebo-treated men; and they and their femalepartners reported improved sexual satisfaction. Pryor says an effective specific treatment could do for prematureejaculation what Viagra did for erectile dysfunction– taking away the ’express joy’ factor by stimulating open discussion about thedisorder. “Viagra wasn’t a magic pill but it did carry ED into the open and menwho had it learned that they were not alone,” he says. “The discussionthat followed stimulated research that led to other treatments. Ira Sharlip. MD a urology professor at the University of California. SanFrancisco tells WebMD there is a definite be for an effective treatment forpremature ejaculation. “I undergo patients who are really disturbed by this issue and so aretheir wives,” he says. “The current treatments are far fromperfect.” Sharlip says traditional SSRIs work best when they are taken every day andeven then they only work for around two-thirds of patients. “Premature ejaculation is certainly one of the most common forms ofsexual dysfunction among men,” Sharlip says. “Not everyone who has itis bothered by it but for those who are it can be a very bigproblem.” XHTML: You can use these tags: <a href="" title=""> <abbr title=""> <acronym call=""> <b> <blockquote have in mind=""> <have in mind> <code> <del datetime=""> <em> <i> <q have in mind=""> <strike> <strong>

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