Sept. 7. 2006 — The first drug developed specifically for prematureejaculation performed come up in two clinical trials but the new treatmentprobably won’t be available in the U. S any measure soon.
Men in the study who took the experimental drug Dapoxetine developed byJohnson & Johnson Pharmaceuticals in conjunction with ALZA Corp. were ableto keep erections longer than men who took placebos.
Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) but isslightly different from the SSRIs (such as Zoloft. Paxil and Prozac) widelyprescribed for depression and otherpsychiatric disorders.
The medicate was designed to be taken as needed one to three hours before sex,instead of every day. Also it is eliminated from the be more quickly thanother SSRIs.
Hopes that Dapoxetine would become the first drug approved for prematureejaculation dimmed last October when the FDA sent a “not approvable”letter to the manufacturer.
The FDA’s concerns about the drug were not made public. In a news release,ALZA Corp promised to “address questions raised in the FDAletter.”
A spokesperson for Johnson & Johnson told WebMD Thursday that thecompany “remains committed to the global development” ofDapoxetine.
Those who do are often advised on practice techniques to back up. Some receivea prescription for a traditional long-acting SSRI since delayed ejaculationis a common align effect among men who take SSRIs for depression.
This use of traditional SSRIs would be considered off-label since themedications are not specifically indicated for this problem.
Other potential sexual side effects of SSRIs include erectiledysfunction and loss of libido however making the traditionalantidepressants less than ideal for treatment of premature ejaculation. Jon L. Pryor. MD tells WebMD. Pryor is a urology professor at the University ofMinnesota.
With treatment the average measure to ejaculation was 1.75 minutes in theplacebo-treated men. 2.78 minutes in the men treated with 30 milligrams ofDapoxetine and 3.32 minutes in the men treated with 60 milligrams of the drug. The study lasted three months.
Men who took the short-acting SSRI also reported having more control overtheir ejaculations than the placebo-treated men; and they and their femalepartners reported improved sexual satisfaction.
Pryor says an effective specific treatment could do for prematureejaculation what Viagra did for erectile dysfunction– taking away the ’snicker’ factor by stimulating open discussion about thedisorder.
“Viagra wasn’t a magic pill but it did bring ED into the change state and menwho had it learned that they were not alone,” he says. “The discussionthat followed stimulated investigate that led to other treatments.
Ira Sharlip. MD a urology professor at the University of California. SanFrancisco tells WebMD there is a definite be for an effective treatment forpremature ejaculation.
“I undergo patients who are really disturbed by this issue and so aretheir wives,” he says. “The current treatments are far fromperfect.”
Sharlip says traditional SSRIs work best when they are taken every day andeven then they only work for around two-thirds of patients.
“Premature ejaculation is certainly one of the most common forms ofsexual dysfunction among men,” Sharlip says. “Not everyone who has itis bothered by it but for those who are it can be a very bigproblem.”
Related article:
http://facultyblogs.com/blog/dysfunctionerectilef/2007/08/06/premature-ejaculation-drug-promising/
comments | Add comment | Report as Spam
|
